An Ultimate Guide to Gonadotropin Therapy

Pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus is available for initiation and preservation of reproductive axis of a human.

Pulsatile GnRH stimulates biosynthesis of LH (luteinizing hormone) and FSH (follicle stimulating hormone).

As a result, it can initiate the production of endogenous testosterone and spermatogenesis along with virilization and systemic secretion of testosterone. Failure of episodic GnRH secretion of gonadotropin may result in the clinical syndrome of HH (hypogonadotropic hypogonadism).


The use of AAS (anabolic androgenic steroids) may come up in a practical form of HH that is famously known as Secondary Acquired Hypogonadotropic Hypogonadism. To avoid any confusion, it is essential to understand the action of Gonadotropin therapy and selective modulators of the estrogen receptor.

Procedure of Gonadotropin Therapy

Human Chorionic Gonadotropin is effective, and its action is identical to pituitary LH. It is not affected by exogenous hormones and preexisting HPTA suppression. It may directly stimulate the dramatic increase in the production of melanotan 2 and volumes of spermatogenesis and testicular.

The basic goal of gonadotropin therapy is to restore the volume and function of testicular. The dramatic increase in testosterone is always required to avoid or reduce the unfavorable crash effect.

The majority of individuals have larger testes at baseline and HCG is sufficient to restore endogenous testosterone production at the orientation of spermatogenesis along with testicular volume.


The basic goal during the initial few weeks of PCT is to restore instantly testicular function and volume. Dramatic increase in the production of testosterone is necessary to reduce the unfavorable crash effect. HCG is sufficient to restore endogenous testosterone production, in some individuals with larger testes. Induction of spermatogenesis may cause a residual secretion of FSH.  Addition in the production of FSH is best suited for severe cases of HH, and its preparation is not available in lots of individuals.

Fasting Blood Values

SC often administers HCG (subcutaneous) or IM (intramuscular) injections. Before starting PCT, it is essential to establish blood values of baseline.

Similar principles are applied to establish values of cycle blood that are necessary to evaluate recovery. Blood work should be obtained almost four weeks after termination of PCT to determine precise readings. You have to establish the following fasting blood values:

  • Prolactin
  • Cortisol
  • LH
  • Estradiol, Extraction
  • T3 and T4, Free
  • Testosterone
  • TSH
  • Fasting Insulin
  • Somatomedin C
  • Lipid Panel
  • GGT liver value

HCG During Cycle


Nolvadex in combination with HCG should be used during prolonged and high dosage cycle. HCG ED can be combined with ED for almost 7 to 10 days successively or intermittently during the cycle. You can maintain testicular volume during the cycle to improve recovery as compared to atrophied testes and initial PCT. The solution addresses prevention of Leydig cell desensitization that is associated with the use of HCG.

To sum up, HCG is good for bodybuilders because steroids can make health worse and with the help of these injections, they can improve their health. It is essential to consult a doctor and share medical conditions.

Bits And Bobs Of HCG For Bodybuilders

These days, Bodybuilding and HCG are interrelated as Bodybuilding is now more than fun or hobby. So, men are adopting workout more seriously, and even females are getting interested in toning their physique and shaping its structure.


Moreover, as now more people are interested in this niche, physicians and doctors have proposed many different ways to improve bodybuilding experience. Hence, along with heavy workout and exercise, bodybuilders are also using many legal and illegal drugs to get better results in minimum time, HCG is one of them.

What is HCG?

Human Chorionic Gonadotropin is abbreviated as HCG– a hormone found in both male and female in a subsequent level. It is a glycoprotein that contains 237 Amino-acids with a molecular mass 2.57 kDa.

How and why Bodybuilders are using HCG?


Well, HCG is used by the bodybuilders in combo with Anabolic Steroid which is also called as anabolic androgenic steroid shortened as “AAS. When exogenous anabolic androgenic steroids are injected into the male body, the drug reacts with the body negatively and shuts down the natural production of the testosterone and prevents releasing of luteinizing hormone.

Henceforth, when the workout of bodybuilders is finished HCG is used at the end or during steroid cycles to bring the testosterone production to its natural level and to restore testicles to its original size

Along with this, HCG is also used as a low-calorie diet suitable especially for those worried about their excessive weight. Ms, Simeons, studying over pregnant women in India, negated it as a calorie deficient diet as it contains maximum 480 calories. Males and females with chubby bodies are now getting treated with the low doses of HCG drug for a slim physique.



HCG helps your body to maintain its shape in various ways such as:

  • Shrink testes to its original size
  • Helps you to avoid side effects of AAS
  • Burns off extra layers of fat
  • Help bodybuilders to get better and smooth muscles
  • Lose the weight for those who want to build their bodies to become handsome as hunks



Here are the negatives of HCG

  • Continuous HCG usage results in abnormal sperm production which is a bad sign for your health
  • Weight Lose quality is real but isn’t reliable because you have to keep your diet low to maintain the wasted level of your body.
  • To maintain weight loss, you will have to eat less than normal, and less intake of food can lead you to some serious health issues.
  • Acne in both male and female
  • Increase risk of multiple pregnancies in females
  • Cause Breast development in men
  • Tiredness in both male and female
  • Hair loss in men and women
  • Excessive fluid retention in men

Note: Due to its excessive side effects, HCG is banned by FDA to use as a diet. Anyhow if you are a bodybuilder and consuming it, try to decrease its intake amount and get proper medical checkups to avoid its side effects.

7 things to know about HCG in Bodybuilding

Eye catching body is a dream of gym lovers. They can frame their bodies quickly if they know which supplement can serve them in a better way. Professional gym owners and bodybuilders are considered a final authority in getting assistance; however, numerous of them have a different opinion about supplements to use. When you question the validity of Human Chronic Gonadotropin (HCG), experts recommend its authenticity in spite having different goals and varied workout style.


Know How to Use It

Some bodybuilders amalgamate it with a steroid to increase the production of testosterone. You can also inject it into your body with injection by adding small traces of calorie diet. A great quantity of calorie could be a cause of unnecessary fat. In a week, use its dose range from 700 to 1750 IU. Researchers and the practical outputs have verified its authenticity, so it is a safe choice. However, overdose can be harsh so evade it.

Normalizing the Testicular Function


Impaired testicular functioning damages the overall health of men. Ingestion of anabolic steroid could harm their proper functionality. HCG keeps every aspect of the body under its normal condition, and you enjoy the spice of perfect health. In addition, its use is effective at the end of an anabolic-androgenic steroid cycle to prevent the collapse of hard earned muscles. They get a much-defined look as they desired.

Post Cycle Therapy (PCT)

When you are on the workout to get strength and muscles gains, your body’s hormonal level doesn’t remain balanced. Keep the hormonal level normal; otherwise, your all efforts may go in vain. PCT protocols have emerged productive medium to sustain muscles. Along with this, utilization of Human Chorionic Gonadotropin works amazingly.



The pituitary produces HCG hormone. Being a natural analog of LH, it stimulates the sex hormone production in ovary or tests. Similar to LH, it energizes, binds and makes the functional receptors to get the desired output – testosterone production. However, while pregnancy; it is more beneficial to its counterpart LH. Later choice has some limitations.


After separating this hormone from the urine of pregnant women, this hormone is highly purified and processed with the extensive care to get the best quality. However, in the market, try to figure out the genuine pharmaceutical brands of HCG otherwise you have to experience inconveniences. It is generally available in the form of lyophilized powder, typically at 5000 or 10,000 IU per vial.


Recombinant DNA Technology and Urine Base HCG

As HGH is manufactured, similarly, it can be produced by the recombinant DNA technology. You can avail it in the form of preloaded syringes. But, the bitter fact is, it hasn’t produced enthusiastic results.

The source of urine-based HCG in the bloodstream during pregnancy contains numerous subunits in the form of monomers that prove to be more effective.


Before its usage, you have to take into consideration all aspects. Consultation with the doctor about its usage is a logical move. Some people have been the prey of acne, hair loss, tiredness, excessive fluid retention and breast development in men due to the usage of HCG.

6 Facts of HCG Bodybuilders should know about

Developing and maintaining the muscles mass is not an automatic process for the bodybuilders. They have to use various techniques to develop and maintain muscles in a specific figure. The techniques may involve a diet plan, injections, supplements and of course regular exercising. Use of Human Chorionic Gonadotropin has also become a good idea for muscles builders. In fact, HCG is a medical drug which is used to treat any disease or problem in a body. But there are also non-medical uses of it. Bodybuilders use HCG to increase their muscles mass through a proper plan with exercise under a best medical and body instructor. Here is a complete explanation about what are the HCG side effects can be expected during bodybuilding? To know about HCG, first make your mind clear by understanding the function of HCG:


What is the HCG Function for Bodybuilders

HCG stands for Human Chorionic Gonadotropin. It is a hormone, which works for testosterone levels for bodybuilders. Balanced Testosterone levels are necessary to increase muscles mass and energy. These hormones development is the continuing process of aging. However, injecting these hormones artificially for bodybuilders becomes a trend. For the muscles gain its use is accompanied with anabolic androgenic steroids.

Body Types Are Different – Know the Facts

Natural production of hormones in a body does not pilot to any side effect unless it is come up to the balance level. Any artificial or extra intake of food or medicine may create certain unwanted issues in the body. There are some side effects which may cause of using HCG for bodybuilders:


  1. It may lead to some allergic irritation, shortness of breath, throat issues, fatigue,
  2. It can increase the blood thickness in the body which tend to produce the blood clot. The thickness of blood causes a headache, redness and swelling in arm or leg.
  3. It can cause many hormonal issues which can be a reason of glands in the body.
  4. For women, the use of HCG for bodybuilding purpose can cause the fertility issues. So the use of HCG should be immediately stopped if she finds herself pregnant. It may also be a root of multiple births which is considered high-risk pregnancy.
  5. The ovarian Hyperstimulation disease in a woman can also be a cause of HCG use. The symptoms of this problem are pelvic soreness, difficulty in breathing, less urination or nausea.
  6. Another complication related to Human Chorionic Gonadotropin is Gynecomastia. It is the abnormal augmentation of the breast in men. It results because the use of HCG converts testosterone into estrogens. Estrogens are the hormones which play a role in the development of female features.
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The use of HCG is not much sensitive, but these are the some complications which should never be ignored by the body builders. They must search well about the HCG plan, precautions, and side effects. Under a senior doctor and practitioner, it can be implemented successfully.

This article will help you to discover the HCG side effects during implementing HCG plan. If anyone found more to these, the comment box is below to share with us.