An Ultimate Guide to Gonadotropin Therapy

Pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus is available for initiation and preservation of reproductive axis of a human.

Pulsatile GnRH stimulates biosynthesis of LH (luteinizing hormone) and FSH (follicle stimulating hormone).

As a result, it can initiate the production of endogenous testosterone and spermatogenesis along with virilization and systemic secretion of testosterone. Failure of episodic GnRH secretion of gonadotropin may result in the clinical syndrome of HH (hypogonadotropic hypogonadism).


The use of AAS (anabolic androgenic steroids) may come up in a practical form of HH that is famously known as Secondary Acquired Hypogonadotropic Hypogonadism. To avoid any confusion, it is essential to understand the action of Gonadotropin therapy and selective modulators of the estrogen receptor.

Procedure of Gonadotropin Therapy

Human Chorionic Gonadotropin is effective, and its action is identical to pituitary LH. It is not affected by exogenous hormones and preexisting HPTA suppression. It may directly stimulate the dramatic increase in the production of melanotan 2 and volumes of spermatogenesis and testicular.

The basic goal of gonadotropin therapy is to restore the volume and function of testicular. The dramatic increase in testosterone is always required to avoid or reduce the unfavorable crash effect.

The majority of individuals have larger testes at baseline and HCG is sufficient to restore endogenous testosterone production at the orientation of spermatogenesis along with testicular volume.


The basic goal during the initial few weeks of PCT is to restore instantly testicular function and volume. Dramatic increase in the production of testosterone is necessary to reduce the unfavorable crash effect. HCG is sufficient to restore endogenous testosterone production, in some individuals with larger testes. Induction of spermatogenesis may cause a residual secretion of FSH.  Addition in the production of FSH is best suited for severe cases of HH, and its preparation is not available in lots of individuals.

Fasting Blood Values

SC often administers HCG (subcutaneous) or IM (intramuscular) injections. Before starting PCT, it is essential to establish blood values of baseline.

Similar principles are applied to establish values of cycle blood that are necessary to evaluate recovery. Blood work should be obtained almost four weeks after termination of PCT to determine precise readings. You have to establish the following fasting blood values:

  • Prolactin
  • Cortisol
  • LH
  • Estradiol, Extraction
  • T3 and T4, Free
  • Testosterone
  • TSH
  • Fasting Insulin
  • Somatomedin C
  • Lipid Panel
  • GGT liver value

HCG During Cycle


Nolvadex in combination with HCG should be used during prolonged and high dosage cycle. HCG ED can be combined with ED for almost 7 to 10 days successively or intermittently during the cycle. You can maintain testicular volume during the cycle to improve recovery as compared to atrophied testes and initial PCT. The solution addresses prevention of Leydig cell desensitization that is associated with the use of HCG.

To sum up, HCG is good for bodybuilders because steroids can make health worse and with the help of these injections, they can improve their health. It is essential to consult a doctor and share medical conditions.